Abstract
Summary
Although rats with chronic pyelonephritis do not develop hypertension directly, they show an increased sensitivity to DOCA hypertension and in addition pyelonephritis aggravates a pre-existing hypertensive disease. The purpose of this experimental study was to explore several possible mechanisms involved in these relationships. The likelihood that changes in the renin content of the kidney of pyelonephritic rats are associated with these phenomena first was investigated and it was demonstrated that extracts of scarred pyelonephritic kidneys contained the same amount of renin-like material as controls. In a separate experiment it was shown that the acute vascular reactivity of pyelonephritic rats to intravenous angiotensin and phenyllysine vaso-pressin was normal. These findings suggest alternate etiologic linkages between hypertension and chronic pyelonephritis such as changes resulting from impaired sodium and water homeostasis.
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