Abstract
Summary
Isolated, hepatic cell plasma membranes bound on average 160 ± 2 μg of sulfobromophthalein (BSP) per mg of protein. Taurocholate, bilirubin and fluore-scein, which do not compete for hepatic uptake with BSP when simultaneously injected in vivo, exhibited little or no interference with BSP binding by hepatic cell plasma membranes in vitro. Other organic anions, such as indocyanine green, flavaspidic acid glucaminate, and iodipamide methylgluca-mine, which compete with BSP for hepatic uptake in vivo, significantly reduced BSP binding by isolated membranes in vitro.
Get full access to this article
View all access options for this article.