Abstract
Summary
A study was made of the sub-cellular distribution of the (3H) corticoste-rone fraction in the brain, thymus, heart, and liver of the rat 30 minutes after IV injection of the steroid. Each tissue fraction was extracted and subjected to purification procedures to remove labeled metabolites. Corti-costerone was present in all subcellular fractions of the tissues studied and the liver was the only organ capable of concentrating cor-ticosterone. Most of the activity was found in the supernatant of each tissue. Some differences occurred in the subcellular distrituition of the (3H) corticosterone fraction in different tissues. Distribution within the liver was different from that in other tissues. This difference is of interest because of the wide range of effects that result after glucocorti-coid treatment. The subcellular distribution was similar in extrahepatic tissues whether they are recognized target tissues of corticosterone or not.
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