Abstract
Summary
Of a series of neuromuscular blocking agents microinjected into the hippocampus, only d-tubocurarine (dTC) was highly selective in establishing a focus at injection sites. These findings coupled with the ineffectiveness of cholinomimetics to antagonize the dTC focus emphasize the differences between the actions of neuromuscular blockers on hippocampal and neuromuscular transmission. Potency of dTC and characteristics of the focus also suggest that dTC acts similar to picrotoxin by interfering with presynaptic inhibition.
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