Abstract
Summary
It is concluded from the present H3TDR autoradiographic study of mouse femora that 5% oxygen leads to suppression of proliferation in an intact periosteum and cessation of proliferation when the periosteum is injured. The deleterious effects of 100% oxygen on the proliferation of cells are not realized at the fracture site, perhaps because of the protection afforded by the existing anoxia. In the intact limb there is evidence to show an early deleterious effect of 100% oxygen.
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