α-6-Deoxyoxytetracycline II. Activity in Chemotherapeutic Studies In the Mouse

Abstract

Summary

DOOTC, a new tetracycline antibiotic, was compared in protection studies in mice with MOTC, DMCT, and TC. Marked advantages of DOOTC over the other tetra-cyclines were demonstrated as follows: 1. Pre-infection protocol: DOOTC demonstrated greater Chemoprophylactic Persistence Time 50% values when administered at equal, at one-half, and, in one instance, at one-quarter the dosage used for the other tetracyclines against the Gram-positive organism S. aureus and the Gram-negative organism P. multocida. 2. Post-infection protocol: DOOTC demonstrated greater Survival Time 50% values in every instance when administered at equal, at one-half, and at one-quarter the dosage used for the other tetracyclines. The persistence time of DOOTC at antibacterial concentrations within the host, and its chemo-therapeutic efficacy in protecting mice from established infections, are advantageous properties and suggest possible advantages in clinical situations.