Abstract
Summary
Splenectomy one day before antigen will inhibit completely the response to i.v. SRBC, but will depress the response below normal levels when performed 8 or 14 days after antigen. Secondary response is inhibited by splenectomy prior to the second injection of antigen. This appears to be different from results obtained with S. typhi flagellar antigen, in which no effect of splenectomy on secondary response can be demonstrated. This suggests that the anamnestic response to i.v. injections of SRBC depends on the presence of the spleen.
Get full access to this article
View all access options for this article.