Abstract
Summary
Quantitation of leukocyte influx into the croton oil-induced pouch in rats was performed, and the effects of 5.0 mg of prednisolone injected daily directly into the pouch determined. Prednisolone reduced the volume of the exudate as well as the total numbers of leukocytes mobilized into the irritated site. The decrease in the numbers of PMNs in the pouch exudate was greater than that seen for other cell types as well as for the reduction in exudate volume. The PMN content of the pouch exudate is suggested as an additional sensitive and reliable criterion for the assessment of anti-inflammatory activity of potential therapeutic agents.
Get full access to this article
View all access options for this article.