Abstract
Summary
Sensitization of guinea pigs to tuberculin by administration of heat-killed human-type, tubercle bacilli 4 weeks before immunization with bovine γ globulin (BGG) emulsified in Freund's complete adjuvant had no apparent qualitative or quantitative effect on the subsequent antibody response to BGG. However, there was an indication that administration of BGG in Freund's incomplete adjuvant to similarly sensitized animals resulted in a response resembling that of animals which received BGG in the complete adjuvant. Evidence was presented to indicate that the mycobacteria used to establish hypersensitivity to tuberculin may also have functioned in an adjuvant role in this case.
Get full access to this article
View all access options for this article.