Abstract
Summary
Chick embryo cells infected with frog viruses No. 1 and 3 were fixed at various times after infection and stained with rabbit antibody labeled with fluorescem iso-thiocyanate. The data show the following: (a) Viral antigens accumulate beginning about 8 hours after infection in discrete cytoplasmic structures which increase in size and become altered with time, (b) Frog viruses No. 1 and 3 cannot be differentiated by immunofluo-rescence with respect to site of antigen accumulation and with respect to reactivity with heterologous antibody(3). Frog viruses differ from herpes simplex with respect to antigenic determinant sites and with respect to pattern of intracellular antigen accumulation.
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