Abstract
Summary
Electrophoretic and peptide fingerprint studies carried out on formic acid extracted collagen from the skins of control and lathyritic rats provided evidence that the excess soluble collagen molecules which accumulate in the tissues of lathyritic animals are intrinsically normal. But the lathyritic molecules are dramatically deficient in aldehyde content. Thus it appears that lathyro-gens exert their effect on connective tissues by causing an inhibition of the oxidative de-amination which appears to precede covalent crosslink formation in collagen and elastin.
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