Abstract
Summary
The complement activity was determined in sera of recipients after reciprocal skin transplantation between two isogenic strains of BN and Lewis rats. Small or massive allografts did not significantly affect the pattern or the level of overall complement activity, despite the fact that these animal sera are known to bind complement in the cy to toxic reaction in vitro. A slight initial rise of the serum complement activity has been noted in most of the animals. This rise is attributed to a possible increase in production of serum protein elicited by bleeding. The results have been interpreted to rule out either an exhaustion or an inactivation of the complement system as a causative factor in the longevity of massive grafts.
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