Abstract
Summary
1. Seven discrete repository sul-fones were tested against M. leprae in mice, and all were found completely suppressive when injected at 2-month intervals. DDS was inactive when given at 2-month intervals, partially suppressive at one month, and completely suppressive at half-month intervals. 2. The repository sulfone 4,4′-diacetyldiamino-diphenylsulfone was titrated in mice against M. leprae. THe least dose giving nearly complete suppression was 6 mg/kg/2 months. Cycloguanil pamoate, a repository triazine antimalarial, was inactive in a dose of 400 mg/kg/2 months. 3. Further tests of the sensitivity of M. leprae to DDS were carried out by feeding the drug in the diet. Two strains were completely inhibited by 0.0001%; the same two and two other strains were insensitive to 0.00001%.
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