Abstract
Summary
A single subcutaneous injection of monocrotaline produced various grades of pulmonary arterial injury including necrotizing arteritis in rats. The arterial lesions were presumed to be sequelae of long standing pulmonary hypertension as manifested by right ventricular hypertrophy. It was noted that monocrotaline could also produce a renal hemosiderosis, as well as glomerular necrosis in association with hyaline thrombosis in the glomerular capillaries and afferent arterioles.
Get full access to this article
View all access options for this article.