Abstract
Summary
Ethacrynic acid produced an increase in calcium and magnesium excretion. This effect was proportional to the degree of natriuresis. Meralluride and chlorothiazide produced less natriuresis and the increment in calcium and magnesium excretion was less. A decrease in phosphate excretion occurred during the diuresis produced by ethacrynic acid. These findings support the thesis that cations, whether monovalent or divalent, are handled in a similar manner by the renal tubule.
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