Abstract
Summary
The maximum bicarbonate output (M.B.O.) of the pancreas in response to secretin and the maximum acid output (M.A.O.) of the stomach in response to histamine have been studied in 5 dogs. The M.B.O. represents mEq for mEq about 30% M.A.O. Calculations from published human data suggest that the pancreas could neutralize the acid output of a normal stomach.
Addendum. Since this paper was prepared, Preshaw and Grossman(11) have reported that the mean maximal rate of secretion of bicarbonate by the dog's pancreas is about one-third of the mean maximal rate of acid secretion by the stomach.
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