Abstract
Summary
Effective beta adrenergic receptor blockade was produced in 8 normal men before, during and after a 14-day period of triiodothyronine-induced hypermetabolism. Triiodothyronine did not augment the increases in plasma levels of free fatty acids during infusions of graded doses of isopro-terenol. The increments in plasma FFA during isoproterenol administration were significantly attenuated by propranolol in the hy-permetabolic period as well as during the initial and final control periods. Neither isoproterenol nor propranolol produced any appreciable changes in blood glucose in any period. The results also suggest that beta adrenergic receptors may mediate the effects of isoproterenol upon free fatty acid mobilization but do not suggest a similar receptor role for regulation of blood sugar levels.
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