Abstract
Summary
Penile ligation (PL) of mice effected a state of anuria which is indistinguishable from anuria effected by bilaterial nephrectomy (BLN) with respect to survival of anuric mice and enhanced lethality when treated with digitoxin. PL-induced anuria probably results from production of a urine stop-flow situation as shown by PSP excretion studies. The PL operation is simpler and faster than the BLN operation and is recommended for production of anuric mice as a research tool.
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