Abstract
Summary
Quantitative febrile responses of normal and tolerant rabbits to 2 purified endotoxins and a heat-killed vaccine were examined after prior incubation in normal rabbit serum and saline. In addition, the effects on febrile responses of varying the age and source of test animals, the type of incubation media and the period of incubation were studied. No evidence of enhanced pyrogenicity of endotoxin incubated in serum was found.
We are grateful to Dr. M. Landy for providing S. typhosa vaccine for these studies, to Mr. Stanley Ward and Mr. Joseph Edelin for expert technical assistance, and to Dr. David Ailing for help in calculation of statistical analyses.
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