Abstract
Summary
Castration of adult male rats resulted in a 5-fold increase in pituitary LH concentration, but no change in pituitary FSH concentration. Estrone, testosterone, δ 4 Androstenedione and dehydroepiandrosterone inhibited the post-castration increase in pituitary LH and there was a relationship between dose and degree of inhibition. Those steroids which exhibited an androgenic effect increased the pituitary FSH concentration in the castrate pituitary, but a dose-response relationship was not discernible.
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