Abstract
Summary
Methylation of t-RNA is studied both in vivo and in vitro in rat liver. Addition of either vitamin B12 or DMBC-coenzyme to the in vitro system improves significantly the rate of methyl incorporation from methionine-C14H3. Cold S-adenosylmethionine does not dilute the radioactivity incorporated from serine-3-C14. An alternate pathway of t-RNA methylation involving methyl-B12 is suggested.
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