Abstract
Summary
A comparative study was made of the toxicity and convulsion activity of 1,1-dimethylhydrazine (UDMH), monometh-ylhydrazine (MMH), and their pyridoxal and pyridoxal-5-phosphate hydrazones. The hydrazones. of UDMH are more toxic than UDMH itself when 3 criteria are compared: a) lag-time before convulsions at various dose levels, or b) time of death, or c) LD50. In the case of MMH, the convulsion times of hydrazones and free hydrazine are about equal; death appears earlier with the hydrazones.
This work implies that pyridoxa exacerbates rather than alleviates the convulsant activity of UDMH and MMH, and thus should not be considered an antidote.
The authors wish to thank Mr. George Ledin, Jr. for his help in statistical analysis of the data, and Mr. Eric Gustavson for excellent laboratory assistance.
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