Abstract
Summary
The effects of acutely induced ischemic heart failure on myocardial high energy phosphate stores were studied in dogs following an abrupt reduction (avg. 40%) of left main coronary arterial flow. Left ventricular biopsies were obtained before and during the onset of heart failure. Myocardial ATP stores were unchanged (control, 6.65 μmoles/g; ischemia, 6.66 μmoles/g) at a time when left ventricular end-diastolic pressure had risen from 3.9 to 11.3 mm Hg and left ventricular stroke work had fallen from 7.9 to 4.9 g-m. The average myocardial creatine phosphate (CP) stores fell from 13.2 μmoles/g to 7.9 μmoles/g. These results indicate that acute ischemic heart failure is not initiated by a detectable depression in total myocardial ATP stores.
The able technical assistance of Shirley C. Sea-gren, Richard McGill, and James Ellison is gate-fully acknowledged.
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