Abstract
Summary
Administration of concentrated preparations of interferon of high titer (extracted from either mouse brain or serum and spleen) inhibited the development of splenomegaly induced by Friend virus in Swiss and DBA2 mice. Interferon was effective only when treatment was continued daily throughout the duration of the experiment, and when inoculated mtraperitoneally (rather than intravenously).
We acknowledge with gratitude the excellent assistance of Mile. Chantal Bourali and Mile. Marie-Thé rèse Thomas. Dr. Raymond Latarjet kindly supplied us with the Friend virus and with a large number of Swiss mice which permitted us to start a colony of these mice. We are indebted to Dr. Charles Chany and to Dr. Rebecca Falcoff for discussion and help in preparation of this report, and to Mr. Philippe Lazar and Mrs. Suzanne Gué guen for analyzing our experimental results and aiding us in their presentation. We should like to thank Dr. John F. Enders for reviewing this manuscript and Dr. Sidney Farber for constant encouragement and advice.
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