Abstract
Summary
A total of 8 mongrel dogs was bled 56-65% of calculated blood volume at rates of 5-14 m1/min. At the end of 60 minutes in hypovolemia the animals were treated experimentally in the following manner: 1) 3 dogs were given no infusion; 2) 2 dogs were infused with an emulsion containing no fat; and 3) 3 dogs were infused with an emulsion containing fat (15% cottonseed oil). The infusions were administered in a volume equivalent to the volume of blood withdrawn. Dogs which received no intravenous infusion died within 3 1/2 hours after massive hemorrhage. Animals infused with an emulsion containing no fat recovered from the experimental hemorrhage but were not physically active within the first week of the posthemorrhagic period. Dogs infused with complete emulsion recovered rapidly after massive hemorrhage and accepted food and water within a few hours after regaining consciousness. These animals were fairly active during the first week after massive hemorrhage and recovered without event within two weeks. All dogs receiving infusions lived longer than 4 months.
The authors wish to thank Colonel William W. Cox, U. S. Surgeon General's Office, for suggestions which led to the studies of this report. Also, thanks are extended to Dr. Curt Meyer, Upjohn Co., Kalamazoo, Mich., for Lipomul IV used for these studies.
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