Abstract
Summary
The biosynthesis of thiamine from 2-methyl-4-amino-5-hydroxymethylpyrimidine and 4-methyl-5-(hydroxyethyl) thiazole, or from their pyro-and monophosphate esters respectively, was inhibited by pyridoxal. Pyridoxal was shown to inhibit the conversion of thiamine monophosphate to thiamine by a cell-free enzyme system prepared from baker's yeast.
The author wishes to thank Mr. Robert Wei and Mr. Robert Domush for skillful technical assistance in this work, which was supported, in part, by grant AM-08393 from Nat. Inst. of Health, U.S.P.H.S.
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