Abstract
Summary
Studies with close arterial injection technique have demonstrated that the renal excretion of 3MG, L-glucose, L-galac-tose, L-fucose and L-mannose was greater than that of the simultaneously injected inu-lin, suggesting a renal tubular secretion of these compounds. Steady-state experiments also showed that a positive T value was obtained with L-glucose and 3MG. Phlorid-zin abolished the tubular secretion of these compounds. It is therefore postulated that a carrier system for sugar transport is located in the brush border of renal tubules. This carrier has a complementary structure resembling that of hexoses. Its luminal site reacts complementarily with D-hexoses and the cyto-plasmic facing site of the carrier reacts with the 3MG and L-hexose.
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