Abstract
Summary
Intravenous administration of the cells obtained from the future donor's spleen sensitized recipient animals to early but not to late kidney allografts. This early sensitization was prevented by giving increased numbers of spleen cells grown in hyperoxic organ culture. Using antigenic fractions extracted from donor spleen cells for pretreatment a measure of graft protection (prolongation) was produced. The survival was further increased by adding 6-MP to the pretreatment regimen. Because of specificity, direct dose relatedness and potentiation by 6-MP, it is thought that neither antigenic competition nor enhancement are involved, but that partial adult tolerance is the mechanism responsible for the delayed rejections seen in these studies.
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