Abstract
Summary
Lactate, isocitrate, malate, glu-tamate, and glucose 6-phosphate dehydro-genases and aldolase were examined in the absence and presence of 9 lanthanide chlorides. All these enzymes were inhibited, although not to the same extent. The forward direction of the glutamate dehydrogenase reaction (glutamate deamination) apparently is not sensitive to the lanthanides, although marked inhibition is observed when a-ketoglu-tarate is substrate (reverse direction). The results reveal that all the lanthanides tested (atomic numbers 57-71) can inhibit enzymes sensitive to metals, whereas the fatty-liver response in vivo is elicited only by lanthanides with atomic numbers 57-62. The experimental data reveal that lanthanide inhibition in vitro is probably a typical heavy-metal effect.
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