Abstract
Summary
Two host responses developed in rats 24 hours after CCI4 injections sub-cutaneously: (1) tense, ballooned-out granu-lomas; (2) dense leucocytic invasion, edema and necrosis of cutaneous muscle. These responses were inhibited, or significantly modified, in rats receiving SK-P or trypsin orally. Epsilon aminocaproic acid blocked the anti-inflammatory and granuloma-inhibiting effects of trypsin or SK-P. Papain, bromelain, chy-motrypsin and Aspergillus protease were inactive. The important implications of the data are: (1) that orally administered trypsin or SK-P is active in modifying the inflammatory response to CC14, and (2) that the action of these substances is related to their enzymatic activity.
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