Abstract
Summary
Antibodies to a sheep anterior pituitary (SAP) preparation and human chorionic gonadotrophin (HCG) have been developed in mouse ascites fluid. The ascites fluid was biologically assayed by the rat ovarian weight response to concurrently injected gonadotrophin. The anti-SAP ascites fluid contained antibody capable of completely blocking the biological activity of rat pituitary gonadotrophin. Likewise, the anti-HCG ascites fluid completely inhibited the activity of as much as 10 IU of HCG. Anti-HCG ascites fluid did not inhibit the biological activity of either SAP powder or rat pituitary gonadotrophin.
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