Renal Changes in Dietary Hepatic Injury in Rats. ∗

Abstract

Summary

The renal changes observed in rats fed a cirrhosis producing diet manifest themselves in autolysis of tubular cells. They appear to be identical with similar changes reported in vit. E deficiency as a rapid post mortem occurrence. Supplements of vit. E will prevent this tendency to rapid autolysis. Lipotropic factors (choline, methionine, and vit. B₁₂) are equally active, (methionine only when mixed with the diet) even in the absence of vit. E.