Abstract
Summary
1. MEA synergizes with pentyl-enetetrazole to produce death in mice when it is injected simultaneously with it, or at 15, 30, 60, or 120 minutes preceding it. Thus, MEA has a stimulant action which comes on rapidly after intraperitoneal injection and endures for at least 2 hours. 2. A central depressant, pentobarbital, does not interact le-thally with MEA when injected prior to MEA. When MEA was injected simultaneously with or 15, 30, or 60 minutes prior to pentobarbital, it increased pentobarbital lethality. These results are most logically explained by assuming competitive interference with barbiturate metabolizing enzymes by the agents.
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