Abstract
Summary
Serum electrophoretic changes in animals receiving allotransplantation of the heart were studied. Two major changes were observed: an early elevation in alpha-2 globulin and a late (post rejection) increase in gamma globulin fraction. The rise of alpha-2 globulins could not be correlated with cytotoxic changes leading to rejection. It is therefore felt that the initial rise in alpha-2 globulin represented a non-cytotoxic graft specific antibody. The change in gamma globulin seemed to be closely related to rejection and possibly represented cytotoxic graft specific antibody.
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