Abstract
Summary
Contact-inhibited, non-replicating primary amnion cell monolayers responded to physiological concentrations of hydrocortisone with replication and increase in cell density, total cellular protein and DNA in the cultures. There was no evidence of cell transformation over long periods of steroid treatment. It is concluded from these data that hydrocortisone provided a stimulus to metabolic activity sufficient to overcome contact-inhibition, or induced alterations in the cytoplasmic membranes in situ which allowed expression of the normal growth potential of the primary cells.
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