Abstract
Summary
Transfer of rabbit blood incubated with endotoxin in vitro or in vivo to a recipient rabbit or a heart-lung preparation induced hyperreactivity of pulmonary blood vessels to acetylcholine after a latent period comparable to that observed after injection of endotoxin. We could not demonstrate the presence of metabolic products of endotoxin or secondary substances capable of inducing immediate alteration of vascular reactivity to acetylcholine after passive transfer to a recipient animal.
The authors wish to express their grateful acknowledgment to Mr. J. Ng for his skillful technical assistance.
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