Abstract
Previous investigators have shown that either a single injection of over 5 units per kilogram cholecystokinin (CCK) or injection of 0.5 unit/kg/min CCK inhibits gastric secretion(2). Recently we showed that injection of pancreatic juice or alkali into the duodenum increased gastric secretion, and injection of relatively small doses of secretin stimulated gastric secretion(7). Preshaw and Grossman have also found that small doses of secretin or CCK sometimes increase gastric secretion(5,6). The present paper is a study of the effects of CCK on gastric secretion in the dog.
Methods and results. Our whole experiment was carried out on ten 6- to 16-kg dogs equipped with Heidenhain pouches which had previously developed a secretory plateau during the third hour after feeding 200 g of proprietary dog food per hour (Fig. 1). A single intravenous injection of 1-5 units CCK‡/kg or continuous injection of 0.5 unit CCK/kg/ min inhibited gastric secretion.
Experiments with food stimulation. A continuous infusion of 0.003 to 0.005 unit CCK/ kg/min was given after a control period in 15 experiments on 5 dogs. There was an immediate, significant rise both in volume (13.3 ± 2.7 ml/hr to 22.3 ± 4.3 ml/hr) and in acid (2.04 ± .43 mEq/hr to 3.35 ± .71 mEq/hr) after the CCK was started (p> 0.01). After the CCK was discontinued, the volume and acid returned to their previous levels (Fig. 2). The secretions for the fourth and fifth hours did not increase in 7 control experiments while in all 15 experiments where CCK was given there was an increase. Analyzing the data using Finney's 2 × 2 contingency table(l), the possibility that this occurred by chance is very slight (p> .002).
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