Abstract
Summary
Explant cultures of newborn hamster thyroid tissue were readily transformed by SV40 and the LLE46 strain of adenovirus 7. The SV40 and adenovirus 7 “T” antigens were present in the majority of LLE46 transformed cells, while the SV40 “T” antigen was present in SV40 transformed cells. When LLE46 transformed cells were injected into hamsters, they produced tumors with histological characteristics of adenovirus-type neoplasms. Tumors produced by SV40 transformed cells were predominantly fibro-sarcomas, but also contained areas of adeno-carcinoma with well defined follicular structures.
The authors are grateful to Dr. Richard A. Malmgren for assistance with immunofiuorescent studies, to Frances Y. Legallais, Frances J. Paul and Paula G. Carney for technical assistance and to John W. McGuire for photomicrographs.
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