Abstract
Summary
A derivative of biguanide, N1-furfurylbiguanide hydrochloride (FFB), has been found to possess an inhibitory effect in chick embryo fibroblasts or monkey kidney cells on the plaque formation of RNA viruses, such as Newcastle disease virus (NDV), the WSN strain of influenza A virus, vesicular stomatitis virus (VSV) and type 1 polio-virus either by drug-in-agar disc (diffusion) or drug-in-agar overlay (dilution) assay. Cyto-toxicity of the compound was reduced when tested in tube cultures instead of plaque assays. Both toxic and effective concentrations of the compound decreased when the amount of Bacto-agar in the maintenance solution was increased, holding the same chemotherapeutic index. The data show that FFB can inhibit selected viruses in suitable host-virus systems and with sensitive methods of detecting virus.
Get full access to this article
View all access options for this article.