Healing of Urinary Bladder Wounds. Morphologic and Biochemical Studies. ∗

Abstract

Summary

The morphologic and biochemical changes during healing of experimental wounds in the urinary bladder of rabbits were studied. A high regenerative capacity was shown. The muscle layers healed by formation of granulation tissue and collagen, whereafter smooth muscle fibers grew into the scar from both sides. There was a rapid increase in the hexosamine and uronic acid content, while simultaneously the hydroxyproline content decreased. One week after wounding all the values were on the normal level. During the rest of the examination period, which lasted until 28 days after wounding, the hydroxyproline content increased steadily. A correlation between morphologic and biochemical sequences could be established.