Inhibition of the Stem-Cell Action of Erythropoietin by Estradiol. ∗

Abstract

Summary

Injection of estradiol into poly-cythemic mice stimulated to produce endogenous erythropoietin inhibited the incorporation of Fe⁵⁹ into their erythrocytes when it was injected during the stage of stem-cell differentiation, but not during the latter stages of erythroid cell development. In doses up to 20 times that of daily endogenous estrogen production, secretion of erythropoietin was not inhibited and utilization of erythropoietin by the bone marrow appeared to be blocked.