Abstract
Summary
Autopsy specimens of human intestine were examined to determine whether the ABO and secretor blood group loci exert the same influence upon levels of intestinal alkaline phosphatase in the mucosa as they do upon levels of the intestinal enzyme in the serum. It was shown that these blood group genes do not significantly affect mucosal alkaline phosphatase, indicating that they do not control capacity to synthesize the enzyme, but rather must play a role in determining rate of secretion into the serum, or in destroying or inhibiting the activity of the enzyme after it is secreted into the serum.
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