Abstract
Summary
The urinary excretion of lyso-zyme was investigated in rats following administration of nephrotoxins. Signs of HgCl2 and UO 2(NO3)2 induced nephroses were accompanied by a moderate lysozymuria. Na2 CrO4 caused a disproportionately high excretion of this enzyme for 3 to 4 days, exceeding normal renal lysozyme content.
Endogenous plasma lysozyme levels increased in nephrectomized rats, indicating an extrarenal source and a renal inactivation of this enzyme. Simultaneous measurements of renal clearances of exogenous lysozyme and creatinine demonstrated a decreased re-absorption of lysozyme in Na2CrO4, but a normal one in HgCl2 dosed rats. The data imply a decreased tubular reabsorption of lysozyme in the pathogenesis of lysozymuria.
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