Comparative Effectiveness of Glucose and Sucrose in Enhancement of Hypersalimentation and Salt Hypertension. ∗

Abstract

Summary

The quantity of 1% saline consumed and the development of salt hypertension in rats were comparably enhanced by addition of either glucose or sucrose in 5% concentration to the drinking solution. Cardiac hypertrophy and lesions were equivalently increased. A curious, and as yet unexplained finding, is that whereas kidney enlargement accompanied consumption of either saline or sucrose-saline solution, such was not the case with glucose-saline. Here the kidney weight did not exceed that of controls, and reno-vascular lesions although present were less pronounced than when other saline solutions were drunk.