Abstract
Summary
Zinc in concentrations in the range of those observed in human plasma and higher inhibited the activity of isolated rat epididymal adipose tissue in the presence of insulin and glucose. Of the other divalent ions studied only mercuric and to a lesser extent cobalt and nickel ions inhibited insulin activity. Zinc inhibition could be prevented in part by dialysis at pH 3.75 but not 7.6. The inhibition by zinc could be prevented by EDTA or large amounts of phosphate.
The authors wish to thank Mrs. Zalfa Sayejrh and Miss Eileen Foster for their technical assistance.
Get full access to this article
View all access options for this article.