Abstract
Summary
Volunteers have been infected with P. tularensis. Maximum fever was seen 4 or 5 days after exposure. The changes in several protein fractions were observed following the infection. A decrease in serum albumin and an increase in α2-globulin occurred 6-7 days after infection. More pronounced changes were seen in the glycopro-teins. The “glycoalbumin” showed a 34% decrease as compared to 5% for serum albumin, “α1-glycoprotein” had a significant increase on day 5. Both the “glycoalbumin” and “α1-glycoprotein” were almost at an 0.05 level of significance by day 3. post exposure, prior to the onset of fever, and reached a significant level of 0.001 on the day of maximum fever.
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