Abstract
Summary
Adenine, hypoxanthine or AICA will not reverse the inhibitory effect of aza-serine on the reproduction of J-128 cells in tissue cultures. Cells exposed to azaserine increase markedly in size with a parallel increase of nuclei size and DNA content. The drug appears to act quite similarly to certain mustards by stopping cell division between S and G2. A lesion appears in the central sphere of attraction in azaserine-treated cells, increases in size and apparently causes death of the cell.
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