Abstract
Summary
The effect of varying concentrations of actinomycin D on the synthesis of viral and cellular ribonucleic acids and on the replication of reovirus type 2 has been investigated. At low concentrations of the antibiotic (0.05 μg to 0.1 μg per ml) which allow maximal yields of infectious virus, the treated cultures exhibited a preferential synthesis of reovirus RNA and a suppression of cellular RNA activity.
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