Abstract
Summary
The results obtained with 24 rabbits show a definite correlation between antigen induced histamine release from rabbit platelets and PCA antibody production. In all cases where there was PCA antibody production there was also antigen induced histamine release, while only 15.4% of the rabbits showed antigen induced histamine release when there was no PCA antibody production. When a comparison between antigen induced histamine release from whole blood and washed platelets was made, it was found that in 74.2% of the experiments washed platelets exhibited the same or better release than whole blood. It is concluded that rabbit PCA antibody is capable of sensitizing rabbit platelets and that free plasma factor and free antibody are not necessary for antigen induced histamine release.
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