Abstract
Summary
The antiviral properties of two substances, dextran sulfate and equine serum, were made use of in combination to distinguish the LSc2ab (Sabin) strain of type 1 poliovirus from other type 1 strains. The combination of inhibitors strongly suppressed plaque formation of LSc2ab virus. In plaque reduction tests with the combined inhibitors 17 or 18 strains of type 1 poliovirus, including attenuated, wild and virulent strains, were unaffected, and these were readily distinguished from the LSc2ab virus.
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